Two cases of life-threatening arrhythmia induced by risperidone: evaluation of risperidone and 9-hydroxy-risperidone concentrations

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Two cases of life‐threatening arrhythmia induced by risperidone: evaluation of risperidone and 9‐hydroxy‐risperidone concentrations

Cases Case 1: A 20-year-old woman suffering a suspected overdose was transported to the hospital. She presented bradycardia with wide QRS waves and QT prolongation, followed by cardiac arrest. Extracorporeal cardiopulmonary resuscitation was implemented, improving circulation. Risperidone and 9OH-RIS levels were 9.6 ng/mL and 127.6 ng/mL, respectively. Case 2: A 54-year-old woman was hospitaliz...

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Risperidone-induced Oculogyric Crisis

Sir, Risperidone in low doses (< 6 mg) is reported to be relatively free from extrapyramidal side effects including dystonia, akathisia, druginduced parkinsonism and tardive dyskinesia (Thomas and Lewis, 1998). A double blind study, which included 388 schizophrenic patients drawn from 20 sites in the United States, reported that the incidence of extrapyramidal symptoms in patients receiving 6 m...

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Risperidone-induced reversible neutropenia

This case report presents a 44-year-old man with a history of schizophrenia who developed neutropenia on risperidone therapy. The patient's laboratory reports showed a gradual decline of leukocytes and neutrophils after resolution and rechallenging. This was reversed with the discontinuation of risperidone and by switching to olanzapine. In this case report, we also discuss the updated evidence...

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Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists".

We have previously reported on the unusual human 5-hydroxytryptamine(7) (h5-HT(7)) receptor-inactivating properties of risperidone, 9-OH-risperidone, bromocriptine, methiothepin, metergoline, and lisuride. Inactivation was defined as the inability of 10 microM 5-HT to stimulate cAMP accumulation after brief exposure and thorough removal of the drugs from HEK293 cells expressing h5-HT(7) recepto...

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ژورنال

عنوان ژورنال: Acute Medicine & Surgery

سال: 2017

ISSN: 2052-8817

DOI: 10.1002/ams2.277